Created in April 1992 by Christine Lavery, president of the MPS Society of the United Kingdom then, with the support and engagement of other MPS organizations around the world, as the MPS Society of Australia, Austria, Germany, Italy, Norway, Poland, Russia, and other organizations that have decided to unite to learn and share their experiences in each country and work to promote better care for families and people with MPS and other related illnesses. As well as working with the medical community to develop treatments so that people affected by MPS and related disorders could have a better quality of life.

The IMPSN mission is to be the primary platform for the MPS and Related Diseases. IMPSN is a global community of informed and empowered organizations, who promote access to medicines, new research, and programs that lead to better quality of lives for patients and those affected by these diseases.