Ophthalmic Manifestations of Patients With Mucopolysaccharidosis
study id #: NCT04770415
condition: Ophthalmic Manifestations
status: Recruiting
purpose:Mucopolysaccharidosis (MPSs) are a group of disorders caused by inherited defects in lysosomal enzymes resulting in widespread intra- and extra-cellular accumulation of glycosaminoglycan(1,2). They have been subdivided according to enzyme defect and systemic manifestations and include MPS IH (Hurler)(3) , MPS IS (Scheie), MPS IH/S (Hurler/Sheie), MPS II(4,5) (Hunter), MPS III (Sanfilippo)(6) , MPS IV (Morquio)(7,8), MPS VI (Maroteaux-Lamy)(9), MPS VII (Sly)(10,11) and MPS IX (Natowicz)(12). Mucopolysaccharidosis have a spectrum of systemic manifestations, including airway and respiratory compromise, skeletal deformities, intellectual and neurological impairment, cardiac abnormalities, gastrointestinal problems and ocular manifestations(13). Ocular manifestation are common in the mucopolysaccharidosis and may result in significant visual impairment(14). Corneal opacification of varying severity is frequently seen, as well as retinopathy, optic nerve swelling and atrophy, ocular hypertension, and glaucoma(14). New treatment modalities for the systemic manifestations of the mucopolysaccharidosis include bone marrow transplant and enzyme replacement therapy have resulted in an improved prognosis in many cases(15).
results: https://clinicaltrials.gov/ct2/show/results/NCT04770415
last updated: February 26, 2022
-
Real-World Data Assessment of Safety of Home-Based and Hospital/Outpatient-Based laronidase Enzyme Replacement Thera...Enzyme replacement therapy (ERT) is avai...
-
International MPS NetworkCreated in April 1992 by Christine Laver...
-
Mucopolysaccharide Storage Disease Type I: Hurler, Hurler-Scheie, and Scheie Syndromeshttps://www.youtube.com/watch?v=en9M2P8S...
-
Significant Neuropsychiatric Symptoms: Three Mucopolysaccharidosis Type IIIB Cases, Two of Whom Were Siblings With a...Mucopolysaccharidosis (MPS) type IIIB pa...
-
Diagnosis of Mucopolysaccharidoses and Mucolipidosis by Assaying Multiplex Enzymes and GlycosaminoglycansMucopolysaccharidoses (MPS) and mucolipi...
-
MPS I: Early Diagnosis, Bone Disease and Treatment, Where Are We NowMucopolysaccharidosis type I (MPS I) is ...
-
Novel Subtype of Mucopolysaccharidosis Caused by Arylsulfatase K (ARSK) DeficiencyMucopolysaccharidoses (MPS) are monogeni...