Trusted Resources: Education
Scientific literature and patient education texts
Analysis of Salivary Parameters of Mucopolysaccharidosis Individuals
source: Brazilian oral research
year: 2022
authors: Nunes PLS,Fonseca FA,Paranhos LR,Blumenberg C,Barão VAR,Fernandes ES,Ferreira RG,Siqueira WL,Siqueira MF,Moffa EB
summary/abstract:Mucopolysaccharidosis (MPS) is a heterogeneous group of rare, chronic, progressive and systemic inherited disorders resulting from deficiency or lack of lysosomal enzymes responsible for the degradation of glycosaminoglycans. Products of nitrosative stress have been previously detected in blood and urine samples of patients with MPS. However, it is unclear whether they are present in the saliva of MPS patients and also if they correlate with salivary parameters such as flow and pH. This study compared the salivary levels of NOX (NO2- + NO3-), nitrite (NO2-), protein (albumin), erythrocyte and leukocyte numbers, as well as the salivary flow rate and pH values of samples obtained from 10 MPS patients and 10 healthy subjects. MPS patients exhibited higher salivary levels of NOX and NO2- when compared to healthy subjects (p < 0.05). Albumin was only detected in six saliva samples of MPS patients and, erythrocytes and leukocytes were detected in 60% and 40% of the MPS patients, respectively. In addition, salivary flow rate and pH averages were statistically lower in this group when compared to healthy samples (p < 0.05). Overall, the data indicates that the salivary levels of NO products can be used in combination with other heath indicators to monitor MPS disorders.
organization: Universidade Federal do Maranhão - UFMA, Hospital Universitário, São Luis, MA, Brazil.DOI: 10.1590/1807-3107bor-2022.vol36.0011
read more
Related Content
-
Advocacy for MPS and MLAdvocacy is the best way for the MPS and...
-
Macular Changes in a Mucopolysaccharidosis Type I Patient With Earlier Systemic TherapiesTo describe retinal findings in a patien...
-
Secondary Ganglioside GM2 Accumulation in MucopolysaccharidosesIn vivo, the lysosomal degradation of GM...
-
Molecular Analysis of Vietnamese Patients With Mucopolysaccharidosis Type IMucopolysaccharidosis type I (MPS I) is ...
-
Glaucoma in MucopolysaccharidosesMucopolysaccharidoses are a group of lys...
-
Hyo-Mental Angle and Distance: An Important Adjunct in Airway Assessment of Adult MucopolysaccharidosisMucopolysaccharidosis (MPS) is a rare co...
-
Significant Neuropsychiatric Symptoms: Three Mucopolysaccharidosis Type IIIB Cases, Two of Whom Were Siblings With a...Mucopolysaccharidosis (MPS) type IIIB pa...