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Understanding Bias When Estimating Life Expectancy From Age at Death: A Simulation Approach Applied to Morquio Syndrome A

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source: BMC research notes

year: 2022

authors: Yin X,Ahn J,Boca SM


Life expectancy can be estimated accurately from a cohort of individuals born in the same year and followed from birth to death. However, due to the resource-consuming nature of following a cohort prospectively, life expectancy is often assessed based upon retrospective death record reviews. This conventional approach may lead to potentially biased estimates, in particular when estimating life expectancy of rare diseases such as Morquio syndrome A. We investigated the accuracy of life expectancy estimation using death records by simulating the survival of individuals with Morquio syndrome A under four different scenarios.

organization: Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA.

DOI: 10.1186/s13104-021-05894-0

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