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Quantitative Brain MRI Morphology in Severe and Attenuated Forms of Mucopolysaccharidosis Type I

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source: Molecular genetics and metabolism

year: 2022

authors: Kovac V,Shapiro EG,Rudser KD,Mueller BA,Eisengart JB,Delaney KA,Ahmed A,King KE,Yund BD,Cowan MJ,Raiman J,Mamak EG,Harmatz PR,Shankar SP,Ali N,Cagle SR,Wozniak JR,Lim KO,Orchard PJ,Whitley CB,Nestrasil I


To assess our hypothesis that brain macrostructure is different in individuals with mucopolysaccharidosis type I (MPS I) and healthy controls (HC), we conducted a comprehensive multicenter study using a uniform quantitative magnetic resonance imaging (qMRI) protocol, with analyses that account for the effects of disease phenotype, age, and cognition.

organization: Division of Clinical Behavioral Neuroscience, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. Electronic address:

DOI: 10.1016/j.ymgme.2022.01.001

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