Trusted Resources: Education
Scientific literature and patient education texts
Oxidative Stress in Mucopolysaccharidoses: Pharmacological Implications
source: Molecules (Basel, Switzerland)
year: 2021
authors: Pierzynowska K,Gaffke L,Cyske Z,Węgrzyn G,Buttari B,Profumo E,Saso L
summary/abstract:Although mucopolysaccharidoses (MPS) are caused by mutations in genes coding for enzymes responsible for degradation of glycosaminoglycans, storage of these compounds is crucial but is not the only pathomechanism of these severe, inherited metabolic diseases. Among various factors and processes influencing the course of MPS, oxidative stress appears to be a major one. Oxidative imbalance, occurring in MPS and resulting in increased levels of reactive oxidative species, causes damage of various biomolecules, leading to worsening of symptoms, especially in the central nervous system (but not restricted to this system). A few therapeutic options are available for some types of MPS, including enzyme replacement therapy and hematopoietic stem cell transplantation, however, none of them are fully effective in reducing all symptoms. A possibility that molecules with antioxidative activities might be useful accompanying drugs, administered together with other therapies, is discussed in light of the potential efficacy of MPS treatment.
organization: Department of Molecular Biology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.DOI: 10.3390/molecules26185616
read more
Related Content
-
Deborah Marsden, MDDeborah Marsden is an Attending Physicia...
-
Hyo-Mental Angle and Distance: An Important Adjunct in Airway Assessment of Adult MucopolysaccharidosisMucopolysaccharidosis (MPS) is a rare co...
-
Nationwide Newborn Screening Program for Mucopolysaccharidoses in Taiwan and An Update of the “Gold Standard&#...Mucopolysaccharidoses (MPSs) are a group...
-
Are You Considering Stem Cell Transplantation? Questions to Ask Your ProviderStem cell transplantation can be an over...
-
Functioning Profiles of Individuals With Mucopolysaccharidosis According to the International Classification of Func...The classification of health problems of...
-
Bone Biomarkers in MucopolysaccharidosesThe accumulation of glycosaminoglycans (...
-
Extraordinary Experiences ProgramProgram provides grants of up to $1000 t...